ARTIFICIAL INTELLIGENCE

DeepMind AI Makes Enormous Leap in Solving Protein Folding Puzzle

December 1, 2020



Software already ate the world, and now it is starting to eat breakthrough scientific discoveries for dessert.  Ok, that’s a bit cheesy, but read on for the meat of the story :).

Google’s DeepMind has created artificial intelligence software that can identify a protein’s 3D shape from its amino-acid sequence to accuracy that is within the width of an atom.

Why is this important?  It solves one of the grand challenges of biology that has been unsolved for 50 years.  Even more significant for DeepMind, “It's the first use of AI to solve a serious problem,” according to John Moult, a computational biologist at the University of Maryland in College Park.

Moult runs a biennial protein-structure prediction challenge called CASP, short for Critical Assessment of Structure Prediction.  In this year’s CASP competition, AlphaFold, DeepMind’s AI algorithm beat out 100 other teams and predicted the structure of dozens of proteins with accuracy matching that of experimental lab techniques such as cryo-electron microscopynuclear magnetic resonance and x-ray crystallography



Protein structure determines function.  Accurately predicting protein structures helps researchers better understand disease as well as speed drug discovery. 

For example, the efforts to develop vaccines for covid-19 have focused on the virus’s spike protein.  Determining protein structure from the amino acid sequence is also known as “protein folding.”

Gamechanger for AI in general and DeepMind in particular
DeepMind has best been known before this for using its AI to master games such as Go, Starcraft, and oh yeah, the entire catalog of Atari video cartridge games.  Demis Hassabis, CEO of DeepMind said, “I do think it’s the most significant thing we’ve done, in terms of real-world impact.”

Yup, for sure, Demis.  Now, DeepMind is out of the parent’s basement and all grown up.


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